Plasma Cell Dyscrasia treatment depends on many factors including but not limited to type of plasma cell disorder, stage of the disease, performance status of the patient, comorbidities, patient’s preference, along with other factors.
Following are the preferred treatment approaches for different plasma cell disorders, but the final decision is taken after clinical assessment of the patient by an oncologist.
|PLASMA CELL DYSCRASIA||TREATMENT|
|Solitary Plasmacytoma||Radiation therapy is the preferred treatment for solitary plasmacytoma. In case of extramedullary plasmacytoma, surgical resection of the affected soft tissue followed by radiation therapy may be employed.|
|MGUS||Patients with MGUS are recommended to be followed-up closely without treatment. Only about 1% of patients with MGUS face progression to multiple myeloma per year.|
|Smoldering multiple myeloma||Patients with smoldering multiple myeloma are also recommended to be followed-up closely without treatment. In case of any sign of disease progression, chemotherapy can be employed as the first line of treatment.|
Patients with the symptomatic disease are recommended to be treated with induction therapy constituting multiagent regimen (mostly a combination of corticosteroid, immunomodulatory drug, and proteasome inhibitor).
After completion of the induction therapy, patients who are the good candidate for stem cell transplant may undergo the procedure if there is an indication.
Maintenance treatment is continued after induction in most patients.
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Following is the brief description of various treatment types employed for multiple myeloma:
It is very important to assess the benefits of each treatment option versus the possible risks and side effects before making a treatment decision. Sometimes, patient’s choice and health condition are also important to make a treatment choice.
Following are goals of treating multiple myeloma:
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