Multiple Myeloma: Symptoms and Early Signs

Multiple Myeloma may present with any one or more of the following symptoms. Sometimes there may be no symptoms, and sometimes other disease conditions may cause similar symptoms. Therefore, further investigations may be required to confirm the diagnosis.

Following are some common signs and symptoms of multiple myeloma-

  • Pain in the affected bone.
  • Osteolytic bone lesion or fracture in the affected bone.
  • Fatigue and weakness attributable to anemia, other anemia-related symptoms may include shortness of breath and dizziness.
  • Recurrent infections like pneumonia due to low WBC count (leukopenia).
  • Increased bleeding tendency due to low platelet count (thrombocytopenia).
  • Unexplained weight loss.
  • High blood level of calcium (hypercalcemia) that may lead to several symptoms like increased thirst and urination, dehydration, abdominal pain, severe constipation, loss of appetite, weakness, drowsiness, and kidney problems leading to kidney failure.
  • Spinal cord compression due to multiple myeloma affecting the spine, which may cause severe pain in the back, leg’s muscle weakness and numbness in legs.
  • Neuropathic pain due to nerve damage.
  • Increased blood viscosity due to the presence of abnormal M protein in high concentration. This may impair the kidney function leading to kidney failure.

Any one or more of the above symptoms if present may require further investigations.

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