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Multiple Myeloma Staging: Revised International Staging System

The multiple myeloma staging system is used to describe the severity of multiple myeloma based on various prognostic factors identified in various clinical research studies. Staging helps doctors to reckon disease prognosis and thus an appropriate treatment strategy can be adopted.

Revised International Staging System (RISS) is the most commonly used system for staging multiple myeloma.

Following table describes the characteristics of multiple myeloma according to different RISS stages:

RISS STAGE DESCRIPTION
I Serum beta-2 microglobulin <3.5 mg/L;
Serum albumin level >/=3.5 g/dL;
Absence of high-risk cytogenetic abnormalities; and
Serum LDH level </= Upper limit of normal
II Neither Stage I nor Stage III
III Serum beta-2 microglobulin >/=5.5 mg/L; and
Either Presence of high-risk cytogenetic abnormalities; or
Serum LDH level > Upper limit of normal

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