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Hypopharyngeal Cancer: TNM Staging and Treatment

Staging systems are used to describe the severity of cancer based on the size, extent of invasion, and spread to different body parts. It helps to determine treatment strategy and disease prognosis. TNM is the most commonly used system for staging hypopharngeal cancers. “T” stands for “Tumor Size”, “N” for “Lymph Nodes”, and “M” for “Metastasis”. Numbers and/or letters after T (is, 1, 2, 3, 4a, and 4b), N (0, 1, 2, and 3), and M (0 and 1) provide more details about each of these factors. Once T, N, and M categories are determined through different diagnostic techniques, this information is combined to assign an overall stage (from 0 to IV) to the disease.

Apart from the stage of disease, the selection of treatment usually depends upon the location of disease, patient’s preference, performance status of the patient, along with other factors. Following are the preferred treatment approaches for different stages of hypopharyngeal cancer, but the final decision is taken after clinical assessment of the patient by an oncologist.

STAGE TNM DESCRIPTION TREATMENT
0 Tis N0 M0 Carcinoma in situ or cancerous lesion is present only in the superficial layer of the hypopharynx. For Stage 0 cancers, surgical resection of the involved site is considered as the standard treatment. The patient should be followed-up closely after treatment for any sign of recurrence.
I T1 N0 M0 The primary tumor is </=2 cm in size. No spread to nearby lymph nodes or distant body parts. For Stage I and II cancers, surgery is considered as the preferred treatment. Surgical resection of the involved site along with lymph node dissection is generally employed. Radiation therapy with or without chemotherapy may be employed after the primary treatment to kill any remaining cancer cells or in the presence of any adverse prognostic features. The patient should be followed-up closely after treatment for any sign of recurrence.
II T2 N0 M0 The primary tumor is >2 cm but </=4 cm in size. No spread to nearby lymph nodes or distant body parts. See Above
III T3 N0 M0 The primary tumor is >4 cm in size or has invaded into the lingual surface of the epiglottis. No spread to nearby lymph nodes or distant body parts. For Stage III to IVA cancers, any of the following 3 approaches can be utilized as the preferred treatment:
1) Start treatment with chemotherapy alone (induction therapy) followed by radiation therapy or radiotherapy + chemotherapy based on the extent of tumor shrinkage with primary treatment.

2) Surgery is employed as the first-line treatment and involves the resection of the primary tumor along with any affected lymph nodes. This is followed by radiation therapy or radiotherapy + chemotherapy based on the presence of any adverse prognostic features.

3) Chemotherapy + radiotherapy or radiotherapy alone can be employed as the primary treatment. Surgery may be employed to remove any remnant cancer tissue.
T1-3 N1 M0 The primary tumor of any size. The disease has spread to a single ipsilateral lymph node measuring </=3 cm without extranodal involvement. No spread to distant body parts. See Above
IVA T1-3 N2 M0 The primary tumor of any size. The disease has spread to a single ipsilateral lymph node measuring either </=3 cm with extranodal involvement or >3 cm but <6 cm without extranodal involvement; or to multiple ipsilateral or bilateral/contralateral lymph nodes, all measuring <6 cm without extranodal involvement. No spread to distant body parts. See Above
T4a N0-2 M0 The primary tumor has invaded any of the adjacent structure, such as larynx, hard palate, or mandible. The disease might have spread to single, multiple, or bilateral/contralateral lymph nodes, all measuring <6 cm without extranodal involvement. No spread to distant body parts. See Above
IVB Any T N3 M0 The primary tumor of any size that might have invaded the adjacent structures. The disease has spread to lymph nodes measuring >6 cm or significant extranodal involvement. No spread to distant body parts. For Stage IVB cancer, radiotherapy along with chemotherapy or targeted therapy is usually employed as the first-line treatment. Surgery may be employed if the tumor shrinks sufficiently that it can be removed with surgery. Radiation therapy may be employed as palliative treatment.
T4b Any N M0 The primary tumor of any size that has invaded a vital structure, such as pterygoid plates, lateral nasopharynx, or skull base and/or surrounds the carotid artery. The disease might or might not have spread to lymph nodes. No spread to distant body parts. See Above
IVC Any T Any N M1 The primary tumor of any size that might have invaded the adjacent structures. The disease might or might not have spread to lymph nodes. The disease has spread to a distant body part, such as the lungs. For Stage IVC cancer, chemotherapy is usually employed as the first-line treatment. Radiation therapy may be employed as palliative treatment.

Palliative Treatment: It helps in improving the overall quality of life by providing relief from the symptoms and by reducing the suffering caused by HNC and its treatment. It is generally given as supportive care for advanced staged HNCs, along with other treatments. It may include but not limited to: using drugs or other interventions to reduce pain, bleeding, and other symptoms; surgical interventions like gastrostomy or tracheostomy to support nutrition or respiration; support and counselling for speech, swallowing, and oral hygiene-related problems; and radiation therapy to palliate pain, bleeding, obstructive problems, etc.

It is very important to assess the benefits of each treatment option versus the possible risks and side effects before making a treatment decision. Sometimes, patient’s choice and health condition are also important to make a treatment choice.

Following are the goals of treatment of Hypopharyngeal Cancer:

  • Prolongation of life.
  • Reduction of symptoms.
  • Improvement of overall quality of life.
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